一种新型钙调蛋白抑制剂合成研究Synthesis of a new calcineurin inhibitor
马矜烁,孙强,闫福林,张纯宝,胡青华
Ma Jinshuo,Sun Qiang,Yan Fulin,Zhang Chunbao,Hu Qinghua
摘要(Abstract)：
以3,4-二甲氧基苯酚为起始原料,经取代、环合、酯还原、脱保护等反应得到新型的钙调蛋白抑制剂3-{2-[4-(3-氯-2-甲基苯)-1-哌嗪基]乙基}-5,6-二甲氧基-1-(4-咪唑甲基)-1 H-吲唑二盐酸化合物,其结构经核磁共振氢谱(1 H NMR)、核磁共振碳谱(~(13) C NMR)、电喷雾离子化质谱(ESI-MS)和高分辨质谱(HRMS)的确证和表征.
The important calcineurin inhibitor,3-{2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl}-5,6-dimethoxy-1-(4-imidazolylmethyl)-1 H-indazole,have been synthesized by the reaction of substitution,cyclization,reduction and deprotection,using 3,4-dimethoxyphenol as the starting material.The structure was confirmed and characterized by nuclear magnetic resonance hydrogen spectrum(1 H NMR),nuclear magentic resonance carbon spectrum(13 C NMR),high resolation mass spetrometry(HRMS)and electrosparay ioniza mass spectrometry(ESI-MS).
关键词(KeyWords)：
3,4-二甲氧基苯酚;钙调蛋白抑制剂;合成
3,4-dimethoxypheno;calcineurin inhibitor;synthesis
基金项目(Foundation): 国家自然科学基金(81172953);; 河南省高等学校重点科研项目(17A350002)
作者(Author):
马矜烁,孙强,闫福林,张纯宝,胡青华
Ma Jinshuo,Sun Qiang,Yan Fulin,Zhang Chunbao,Hu Qinghua
DOI: 10.16366/j.cnki.1000-2367.2018.02.009
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