李建辉,唐敏,陈新,孙中亮,王博
Li Jianhui,Tang Min,Chen Xin,Sun Zhongliang,Wang Bo

• 1:海南大学材料与化工学院

摘要(Abstract)：

介绍了一种以芳基酮酸为原料、无催化剂、以高活性2,2-二氯-1,3-二异丙基咪唑烷-4,5-二酮作为交联剂一锅法合成α-酮酰胺的简便方法.该方法反应条件温和,产率高.在室温下,绝大多数的芳基酮酸和胺反应都能够很好的转化为对应的α-酮酰胺.通过柱层析对粗产物进行纯化以及采用1 H NMR(核磁共振氢谱)和13 C NMR(核磁共振碳谱)对产物结构进行表征.α-酮酰胺类化合物在有机合成上具有很好的潜在应用价值.
A catalyst-free and one-pot synthetic procedure forα-ketoamide fromα-oxocarboxylic acid using high-activity2,2-dichloro-1,3-diisopropylimidazolidine-4,5-dione as crosslinking agent was reported in this paper.The method has the advantages of mild reaction condition and high yield.Most of theα-oxocarboxylic acids and amines can be successfully converted to their correspondingα-ketoamides at room temperature.The crude product was purified by column chromatography and the product was characterized by 1 H NMR(nuclear magnetic resonance hydrogen spectrum)and 13 C NMR(nuclear magnetic resonance carbon spectrum).α-ketoamide compounds have good potential application value in organic synthesis.

关键词(KeyWords)： 芳基酮酸;胺;2,2-二氯-1,3-二异丙基咪唑烷-4,5-二酮;α-酮酰胺
α-oxocarboxylic acid;amine;2,2-dichloro-1,3-diisopropylimidazolidine-4,5-dione;α-ketoamide

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(21502036;31360105;31660128);; 海南省自然科学基金团队研究项目(2016CXTD006);海南省自然科学基金面上项目(217041)

作者(Author): 李建辉,唐敏,陈新,孙中亮,王博
Li Jianhui,Tang Min,Chen Xin,Sun Zhongliang,Wang Bo

DOI: 10.16366/j.cnki.1000-2367.2018.03.011

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