苏坤霞
Su Kunxia

• 1:河南师范大学新联学院公共教学部

摘要(Abstract)：

以4周龄雄性C57BL/6J小鼠高脂饮食饲喂8周构建的营养性肥胖小鼠为实验对象,将成功构建的肥胖小鼠分为肥胖模型组、运动组、奥利司他组和运动联合奥利司他组(联合组).以同批次小鼠饲喂普通饮食作为空白对照组;运动组及联合组进行中等强度的跑台运动,其他组不做运动;奥利司他组及联合组灌胃奥利司他,其他组灌胃奥利司他药物溶剂.8周后比较各组小鼠体质量、Lee's指数、脂肪湿质量、脂肪细胞形态和大小以及小鼠力竭运动时间,研究运动训练联合奥利司他对营养性肥胖小鼠的减肥作用,以及对小鼠运动能力的影响.结果发现,运动和奥利司他均能明显减轻肥胖小鼠体质量、减小Lee's指数、减轻脂肪湿质量和减小脂肪细胞大小;运动能有效延长小鼠力竭运动时间而仅用奥利司他则没有明显效果;运动和奥利司他联合处理具有更好效果,基本可使肥胖小鼠恢复至正常小鼠的状态,尤其是在延长小鼠力竭运动时间作用更加明显.
The 4-week-old male C57 BL/6 Jmice were fed with high-fat diet for 8 weeks to construct a model of nutritive obese mice,the obese mice were divided into obese model group,exercise group,orlistat group and exercise combination with orlistat group(combined group).The normal diet of mice in the same batch was used as the blank control group;the exercise group and the combined group were moderate treadmill exercise,the other groups did not exercise;the orlistat and the combined group were treated with orlistat,and the other groups were treated with orlistat solvent.After 8 weeks,comparative body mass,Lee's index,wet weight of fat,the shape and size of adipocytes of mice and exhaustive exercise time of mice in each group,to study the effect of exercise training combined with orlistat on the weight loss of nutritive obese mice and the effect on the athletic ability of mice.The results showed that both exercise and orlistat significantly reduced body mass,Lee's index,wet weight of fat and the shape and size of adipocytes in obese mice;exercise can effectively extend the time of exhaustive exercise in mice and only with orlistat is no significant effect;exercise and orlistat combined treatment has a better effect,can make obese mice to return to normal state,especially in extend the time of exhaustive exercise.

关键词(KeyWords)： 运动训练;奥利司他;减肥;运动能力
exercise training;orlistat;weight loss;athletic ability

Abstract:

Keywords:

基金项目(Foundation): 江西省自然科学基金(2011ZBAB204028)

作者(Author): 苏坤霞
Su Kunxia

DOI: 10.16366/j.cnki.1000-2367.2018.02.014

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